PhD studentship in developing novel probabilistic modelling and statistical inference methodology and applying these methods to
problems in computational systems biology Department of Information and Computer Science, Aalto University School of Science and Technology (formerly Helsinki University of Technology; http://ics.tkk.fi/en/)
The post is funded as part of a large inter-disciplinary European consortium project on systems approaches to gene regulation biology through nuclear receptors (SYNERGY) which has been funded under the ERASysBio+ initiative. The work will involve close collaboration with other project partners, especially profs. Magnus Rattray and Neil D. Lawrence (University of Sheffield, UK).
In the project, experimental project partners from Germany and the Netherlands will generate high-dimensional and multi-modal time-series datasets interrogating the transcriptional response to nuclear receptor activation, using an array of next-generation sequencing experiments. The data will be used to infer and parameterize systems biology models of cellular function. An iterative process of model inference and experiment will be used to uncover the cellular mechanisms of nuclear receptor function and dysfunction. The methodology developed in the project will build on recent work integrating probabilistic modelling with systems biology modelling [e.g. Proc. Natl. Acad. Sci. USA 107(17), 7793 (2010)].
Candidates must have an MSc degree in computer science, electrical engineering, mathematics, physics, or a related field. A strong mathematical background and an interest in Bayesian modeling and/or machine learning. An interest in systems biology is essential but no prior experience is necessary.
As a PhD student you will join a vibrant research community in the capital of Finland, characterized by a high quality of life and the close proximity of nature. The funding is available initially for three years, with a gross monthly salary ranging from 2000 to 3300 Euro, depending on qualifications and performance. The position will start on 1 August 2010 or flexibly thereafter. The language of instruction is English. For more details and application instructions, see http://users.ics.tkk.fi/ahonkela/phd_po ... 2010.shtml