[παλιό] Inference of Gene Relations from Microarray Data

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Inference of Gene Relations from Microarray Data by Abduction
Ειρήνη Παπαθεοδώρου, Imperial College

Πέμπτη, 22/12/2005, 11:15-12:30 Αίθουσα Α41 (πτέρυγα Αντωνιάδου, κτίρια Πατησίων)

Abstract
We describe an application of Abductive Logic Programming (ALP) to the analysis of an important class of DNA microarray experiments. We develop an ALP theory that provides a simple and general model of how gene interactions can cause changes in observable expression levels of genes. Input to the procedure are the observed microarray results; output are hypotheses about possible gene interactions that explain the observed effects.
We apply and evaluate our approach on microarray experiments on M.tuberculosis and S.cerevisiae.

Short bio:
Irene Papatheodorou is a PhD student at the Department of Computing, Imperial College London since October 2002.
Research objectives: applying AI methods to the analysis of biological data.
Previous academic achievements include an MSc in Computational Genomics and Bioinformatics at Imperial College (2001-2002) and a B.Sc in Human Genetics at University College London (1998-2001).